There have been a lot of discussion and some good white paper references recently on optimizing DNN based sites including modules, skins and server level.  This presentation will walk thru optimization from a skin and module level with best practices and samples of bad and good methods to bettering your site performance. 
Site based optimization covers the following:

• Container and Skin package
  • CSS files combined into one for each package
  • Sprite Image
  • Minimal DOM Elements
  • Avoid CSS Expressions
• Loading of external file and lowering the amount of server requests
  • Combining JavaScripts and libraries into minimal amount of files
  • Eliminating 404 Errors
• Add Expires Headers
• Cache and compression
  • Module
  • Site
  • Compressing JavaScript
  • Initializing GZip on the server

Speakers

Matt Hammer - Design and Skin Engineer from R2integrated
Nick Christy - Director of Technology from R2integrated